|
KMID : 0931320200200010054
|
|
대한상부위장관.헬리코박터학회지
2020 Volume.20 No. 1 p.54 ~ p.62
|
|
|
A Comparison of Accuracy between IMMULITE2000® and GENEDIA® for Helicobacter pylori Infection
|
|
Lim Seon-Hee
Kim Na-Young
Kim Sung-Eun
Baik Gwang-Ho
Lee Ju-Yup
Park Kyung-Sik
Shin Jeong-Eun
Song Hyun-Joo
Myung Dae-Sung
Choi Suck-Chei
Kim Hyun-Jin
|
|
|
Abstract
|
|
|
Background/Aims: In serological tests for Helicobacter pylori (H. pylori), an enzyme-linked immunosorbent assay (GENEDIA®) and a solid-phase, two-step chemiluminescent enzyme immunoassay (IMMULITE®), which are easy to perform, inexpensive, and widely available, are commonly used. However, local validation of the test performance of IMMULITE® is required. This study aimed to examine the performance of IMMULITE® in comparison with that of GENEDIA® in a Korean health checkup population.
Materials and Methods: The sera of 300 subjects among those who underwent health checkup were analyzed using IMMULITE®, and results were compared with those of GENEDIA®. The two serological tests were compared for their ability to predict atrophic gastritis (AG) or intestinal metaplasia (IM) on endoscopy.
Results: We found significant correlation (Pearson correlation coefficient=0.903, P<0.0001) and an almost perfect agreement (Cohen’s Kappa coefficient=0.987, P<0.0001) between the results of GENEDIA® and IMMULITE®. The area under the receiver operating characteristics curve (AUC) for AG using GENEDIA® and IMMULITE® were 0.590 and 0.604, respectively, and showed no statistically significant difference in predictive ability for AG (Z-statistics=-0.517, P=0.605). The AUC for IM by GENEDIA® and IMMULITE® were 0.578 and 0.593, respectively, with no statistically significant difference in predictive ability for IM between the two values (Z-statistics=-0.398, P=0.691).
Conclusions: No statistically significant difference in diagnostic value for H. pylori infection was found between GENEDIA® and IMMULITE®.
|
|
|
KEYWORD
|
|
|
Enzyme-linked immunosorbent assay, Helicobacter pylori, Immunoenzyme techniques, Serology
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|